Drive during your normal "awake" hours to keep your circadian rhythm normal. Assuming you're typically awake during the day and asleep at night, I would get an early jump in the morning. Start driving before the sun comes up, and be done with your drive near sunset. Last thing you want to do is drive at night fighting sleep. Additionally, shift your jump off time/breaks to not hit major city's at rush hour. For a 12 hour drive I would take a quick 10-15 minute break/fuel stop every 3-4 hours, but that's me. I like to get out, stretch, get coffee and get back in. In the end I would rather add an additional hour to my 12 hour drive for the short breaks to keep fresh.
Good luck!
Good luck!
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