For the most part, no, because the suspension geometry is not changing. However, if I noticed any substantial changes in tire wear, I would verify it.
Yes, alignment will be needed to check TOE, camber and tracking front to rear. So long as you keep the lower control arm adjustments the same as pre-lift you should be close enough to put a few miles on. No need to re-align after adjustments are made unless the adjustments are drastic.
Once you've installed the new parts, getting a professional alignment is a must. This isn't just to keep your tires from wearing out unevenly, but also to make sure your car drives and handles the way it should—safely and smoothly. Also, the suspension will settle after the install, so it's a good idea to check everything again after you've driven a bit. If things feel loose, re-tighten them. It's better to be safe than sorry.
I ran mine a few days before adjusting the height and getting aligned and it drove great, but I lowered the adjusters a bit before I installed them. I lowered the front approximately another inch and the rear 1/2”. My son did the alignment and said the only setting significantly off was the camber. I didn’t do any actual measurements except comparing thread exposure from side to side to get them the same. You can put a tape measure on it and check the toe.
